CX3CR1, C-X3-C motif chemokine receptor 1, 1524

N. diseases: 310; N. variants: 10
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0023508
Disease:
White Blood Cell Count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0242383
Disease:
Age related macular degeneration 		0.090 GeneticVariation BEFREE PLEKHA1 958A/G polymorphism was associated with a decreased AMD risk (additive model: aOR=0.722, 95% CI=0.450-0.979, P=0.019; allele model: aOR=0.883, 95% CI=0.736-0.992, P=0.014), while all other polymorphisms were associated with an increased AMD risk (CX3CR1 839C/T, additive model: aOR=2.682, 95% CI=1.119-5.709, P=0.022, recessive model: aOR=2.729, 95% CI=1.141-6.048, P=0.010; CX3CR1 745G/A, additive model: aOR=2.614, 95% CI=1.231-6.012, P=0.020, recessive model: aOR=2.340, 95% CI=1.227-5.993, P=0.011; VEGFA +674C/T, additive model: aOR=1.601, 95% CI=1.253-2.179, P<0.001, dominant model: aOR=1.287, 95% CI=1.058-1.570, P<0.001, allele model: OR=1.220, 95% CI=1.118-1.427, P<0.001; VEGFA +936C/T, additive model: aOR=1.509, 95% CI=1.105-2.311, P<0.001, recessive model: aOR=1.432, 95% CI=1.027-2.192, P=0.009, dominant model: aOR=1.207, 95% CI=1.031-1.514, P0.001, allele model: aOR=1.216, 95% CI=1.062-1.408, P<0.001). 29565837 2018
dbSNP: rs3732379
rs3732379
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0242383
Disease:
Age related macular degeneration 		0.080 GeneticVariation BEFREE PLEKHA1 958A/G polymorphism was associated with a decreased AMD risk (additive model: aOR=0.722, 95% CI=0.450-0.979, P=0.019; allele model: aOR=0.883, 95% CI=0.736-0.992, P=0.014), while all other polymorphisms were associated with an increased AMD risk (CX3CR1 839C/T, additive model: aOR=2.682, 95% CI=1.119-5.709, P=0.022, recessive model: aOR=2.729, 95% CI=1.141-6.048, P=0.010; CX3CR1 745G/A, additive model: aOR=2.614, 95% CI=1.231-6.012, P=0.020, recessive model: aOR=2.340, 95% CI=1.227-5.993, P=0.011; VEGFA +674C/T, additive model: aOR=1.601, 95% CI=1.253-2.179, P<0.001, dominant model: aOR=1.287, 95% CI=1.058-1.570, P<0.001, allele model: OR=1.220, 95% CI=1.118-1.427, P<0.001; VEGFA +936C/T, additive model: aOR=1.509, 95% CI=1.105-2.311, P<0.001, recessive model: aOR=1.432, 95% CI=1.027-2.192, P=0.009, dominant model: aOR=1.207, 95% CI=1.031-1.514, P0.001, allele model: aOR=1.216, 95% CI=1.062-1.408, P<0.001). 29565837 2018
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.020 GeneticVariation BEFREE We assessed whether the 2 common polymorphisms of the CX3CR1 gene (V249I and T280M) modify amyotrophic lateral sclerosis (ALS) phenotype. 28342179 2018
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0742343
Disease:
Acute Chest Syndrome 		0.020 GeneticVariation BEFREE This study shows that CX3CR1 T280M polymorphism does not affect the incidence of ACS the Egyptian population. 30381070 2018
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0948089
Disease:
Acute Coronary Syndrome 		0.020 GeneticVariation BEFREE The Association of Fractalkine Receptor (T280M) Polymorphism in the Pathogenesis of Acute Coronary Syndrome in the Egyptian Population. 30381070 2018
dbSNP: rs3732379
rs3732379
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis 		0.020 GeneticVariation BEFREE We assessed whether the 2 common polymorphisms of the CX3CR1 gene (V249I and T280M) modify amyotrophic lateral sclerosis (ALS) phenotype. 28342179 2018
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset 		0.010 GeneticVariation BEFREE We analyzed the association of the two CX3CR1 functional variants (V249I, rs3732379; and T280M, rs3732378) with neurofibrillary pathology progression rate according to Braak's staging system, age at onset (AAO), survival time, and risk of suffering LOAD. 28343297 2018
dbSNP: rs3732379
rs3732379
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset 		0.010 GeneticVariation BEFREE We analyzed the association of the two CX3CR1 functional variants (V249I, rs3732379; and T280M, rs3732378) with neurofibrillary pathology progression rate according to Braak's staging system, age at onset (AAO), survival time, and risk of suffering LOAD. 28343297 2018
dbSNP: rs750585901
rs750585901
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0036341
Disease:
Schizophrenia 		0.010 GeneticVariation BEFREE We detected a statistically significant association between the variant Ala55Thr in CX3CR1 with SCZ and ASD phenotypes (odds ratio=8.3, P=0.020). 28763059 2017
dbSNP: rs750585901
rs750585901
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C1510586
Disease:
Autism Spectrum Disorders 		0.010 GeneticVariation BEFREE We detected a statistically significant association between the variant Ala55Thr in CX3CR1 with SCZ and ASD phenotypes (odds ratio=8.3, P=0.020). 28763059 2017
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0200637
Disease:
Monocyte count procedure 		A 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0200635
Disease:
Lymphocyte Count measurement 		A 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0750880
Disease:
Monocyte count result 		A 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0004153
Disease:
Atherosclerosis 		0.040 GeneticVariation BEFREE We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS). 27118566 2016
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0003850
Disease:
Arteriosclerosis 		0.040 GeneticVariation BEFREE We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS). 27118566 2016
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0022661
Disease:
Kidney Failure, Chronic 		0.030 GeneticVariation BEFREE We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS). 27118566 2016
dbSNP: rs3732379
rs3732379
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0003850
Disease:
Arteriosclerosis 		0.030 GeneticVariation BEFREE These data demonstrate possible associations between CX3CR1 V249I and CCR5-59029 A/G polymorphisms and/or HT, DM and AS in CRF subjects. 27118566 2016
dbSNP: rs3732379
rs3732379
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0004153
Disease:
Atherosclerosis 		0.030 GeneticVariation BEFREE These data demonstrate possible associations between CX3CR1 V249I and CCR5-59029 A/G polymorphisms and/or HT, DM and AS in CRF subjects. 27118566 2016
dbSNP: rs3732379
rs3732379
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0022661
Disease:
Kidney Failure, Chronic 		0.030 GeneticVariation BEFREE These data demonstrate possible associations between CX3CR1 V249I and CCR5-59029 A/G polymorphisms and/or HT, DM and AS in CRF subjects. 27118566 2016
dbSNP: rs3732379
rs3732379
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0020538
Disease:
Hypertensive disease 		0.020 GeneticVariation BEFREE These data demonstrate possible associations between CX3CR1 V249I and CCR5-59029 A/G polymorphisms and/or HT, DM and AS in CRF subjects. 27118566 2016
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0011849
Disease:
Diabetes Mellitus 		0.010 GeneticVariation BEFREE We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS). 27118566 2016
dbSNP: rs3732378
rs3732378
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0020538
Disease:
Hypertensive disease 		0.010 GeneticVariation BEFREE We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS). 27118566 2016
dbSNP: rs3732379
rs3732379
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0011849
Disease:
Diabetes Mellitus 		0.010 GeneticVariation BEFREE These data demonstrate possible associations between CX3CR1 V249I and CCR5-59029 A/G polymorphisms and/or HT, DM and AS in CRF subjects. 27118566 2016
dbSNP: rs3732379
rs3732379
Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0027051
Disease:
Myocardial Infarction 		0.010 GeneticVariation BEFREE We then explored common and low-frequency variation in South Asians through Pakistan Risk of Myocardial Infarction Study (PROMIS; 9058 cases and 8379 controls), identifying 6 variants associated with MI including CX3CR1 V249I. 27013693 2016